Natural Product Details
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| Identifier | NPBS000004 |
|---|---|
| Compound Name | Quercetin |
| Molecular Formula | C21H20O11 |
| InchiKey | OXGUCUVFOIWWQJ-UHFFFAOYSA-N |
| Pathway | Shikimates and Phenylpropanoids |
| Class | Flavonols |
| Biological Source | Botanical; Zoological; Marine; |
| Molecular Weight | 448.38 |
|---|---|
| Number of Rings | 4 |
| Number of Aromatic Rings | 3 |
| H-bond Donors | 7 |
|---|---|
| H-bond Acceptors | 11 |
| Rotatable Bonds | 3 |
| Mol LogP | 0.48 |
|---|---|
| QED | 0.27 |
| Synthetic Accessibility | 4.0 |
| Description |
|---|
| weak inhibitory activity toward cyclooxygenase-2; highly active against Leishmania (V.) peruviana; effective against Leishmania (V.) brazilienis; anti-herpes simplex virus 1 (HSV-1) activity; inhibition of polyphenol oxidase activity; inhibition of 5- and/or 15-lipoxygenase; inhibition against mushroom tyrosinase; modulate intracellular ROS production; inhibitory effect on MAO-B; anti-Helicobacter pylori; diagnostic fragment ions; leishmanicidal activity; free radical scavenging; inhibition of arginase; novel natural product; inhibition of enzyme; weak antibacterial; antitrypanosomal; weak antifungal; antioxidant; cytotoxic |
| Source Name | Scientific Name | Common Name | Taxon | Source Parts | Traditional Chinese Medicine | COL Link |
|---|---|---|---|---|---|---|
| Abelmoschus manihot | Abelmoschus manihot (L.) Medik. | - | botanical | - |
黄蜀葵花 (HUANG SHU KUI HUA)
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| Abies amabilis | Abies sect. Amabilis (Matzenko) Farjon & Rushforth sensu Earle 2009 | Pacific silver fir | botanical | - | - |
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| Abies bifolia | Abies bifolia A. Murray bis | - | botanical | - | - |
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| Acacia caven | Acacia caven (Molina) Molina | Roman-cassie | botanical | - | - |
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| Acacia confusa | Acacia confusa | small Philippine acacia | botanical | - |
台湾相思 (bark of Taiwan Acacia)
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| Acacia nilotica | Acacia nilotica Schumach. & Thonn. | gum arabic tree | botanical | - |
阿拉伯胶金合欢 (A LA BO JIAO JIN HE HUAN)
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| acacia praecox | Acacia praecox Griseb. | - | botanical | - | - | - |
| Acanthopanax senticosus | Acanthopanax senticosus (Rupr. & Maxim.) Harms | - | botanical | - |
刺五加 (CI WU JIA)
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| acanthophora spicifera | Acanthophora spicifera (Vahl) Borgesen | - | botanical | - | - |
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| Acanthophyllum elatius | Acanthophyllum elatius Bunge ex Boiss. | - | botanical | - | - |
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| Apis mellifera ligustica | Apis mellifera ligustica (Spinola, 1806) | - | zoological | - |
蜂胶 (FENG JIAO)
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| Polyommatus icarus | Polyommatus icarus | - | zoological | - | - |
|
| Title | Journal | Year | Volume (Issue) | Page | PubMed ID | DOI |
|---|---|---|---|---|---|---|
| α-Glucosidase Inhibitors from Vauquelinia corymbosa. | Molecules (Basel, Switzerland) | 2015 | 20 | 15330-42 |
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| Separation of the antioxidant compound quercitrin from Lindera obtusiloba Blume and its antimelanogenic effect on B16F10 melanoma cells. | Bioscience, biotechnology, and biochemistry | 2013 | 77 | 58-64 |
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| Fitoquímica e quimiossistemática de Euxylophora paraensis (Rutaceae) | Química Nova | 2012 | 35 | 2119-2124 | - |
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| The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase. | Experimental parasitology | 2012 | 130 | 183-8 |
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| Quercetin and quercitrin protect against cytokine‑induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling. | International journal of molecular medicine | 2012 | 31 | 265-71 |
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| Chemical constituents of Indonesian plant Protium javanicum Burm. f. and their antifeedant activities against Coptotermes formosanus Shiraki. | Natural product research | 2012 | 27 | 270-3 |
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| Antimicrobial and cytotoxic activities of leaves, twigs and stem bark of Scutia buxifolia Reissek. | Natural product research | 2011 | 26 | 939-44 |
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| Dietary compound quercitrin dampens VEGF induction and PPARgamma activation in oxidized LDL-exposed murine macrophages: association with scavenger receptor CD36. | Journal of agricultural and food chemistry | 2010 | 58 | 1333-41 |
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| Triterpenoids and Flavonoids from Celery (Apium graveolens). | Journal of Natural Products | 2009 | 72 | 1563-1567 |
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| Eucalmaidins A-E, (+)-Oleuropeic Acid Derivatives from the Fresh Leaves of Eucalyptus maideni. | Journal of Natural Products | 2009 | 72 | 1608-1611 |
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